Sjögren's Syndrome and Pregnancy - Study by Karolinska Institutet, Sweden

Prof. Marie Wahren- Herlenius

Photo Anders Nordmann

 

 

Sjögren's Syndrome

 

Sjögren's syndrome is a rheumatic disorder that manifests itself primarily through inflammation of the body's tear and salivary glands, with severe dryness as a result. It is also associated with extreme tiredness and symptoms involving other glands, muscles, joints and the lungs.

 

Professor Marie Wahren-Herlenius. 

We had five questions for Marie Wahren-Herlenius who is researching Sjögren's syndrome and its link to a type of cardiac arrhythmia that can occur during the development of the unborn child in affected women. Marie Wahren-Herlenius is professor of experimental rheumatology at the Department of Medicine, Solna.

 

What causes Sjögren's syndrome?

"The causes are not entirely clear, but it is triggered by a combination of genetic susceptibility and environmental factors. As is the case with other rheumatic disorders, the genetic causes are complex as there are so many different genes involved."

 

Can it be treated?

"There is no cure but we can manage the symptoms to some extent. Ongoing clinical trials give hope for new therapies that could reduce or completely remedy the imbalance in the immune system found in Sjögren's syndrome."

 

Some children of women with Sjögren's syndrome are born with a serious cardiac arrhythmia, known as an AV block. Why is this?

 

"Some people with Sjögren's syndrome, have a kind of antibody in their blood that can pass into the foetus and bind to the surface of the heart's cells. This leads to local cell death in the heart's conduction system and to an impairment of the conduction of the impulses that control the heartbeat, and in a worst case scenario a complete AV block develops. Fatalities are high in such cases, at 20-30%."

 

 

Thanks to your research it is now possible to prevent severe, complete AV blocks. How does this work?

"Treating the foetus with steroids, through the mother, at an early stage of AV block development means that we can prevent a complete block from developing and, in many cases, get the heart to return to a normal rhythm. We can now identify women who are at risk by analysing their antibody profile and taking Doppler measurements, a kind of ultrasound examination, so that we can treat them at the right time."